SRR1455925
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.388
- SPERMATOGENESIS+0.271
- KRAS_SIGNALING_DN+0.186
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.136
- HEDGEHOG_SIGNALING+0.126
- PANCREAS_BETA_CELLS+0.103
- PROTEIN_SECRETION+0.102
- PI3K_AKT_MTOR_SIGNALING+0.055
- APICAL_SURFACE+0.048
- UV_RESPONSE_DN+0.022
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.675
- INTERFERON_GAMMA_RESPONSE-0.590
- IL6_JAK_STAT3_SIGNALING-0.585
- ANGIOGENESIS-0.505
- INFLAMMATORY_RESPONSE-0.503
- ALLOGRAFT_REJECTION-0.478
- COAGULATION-0.464
- TNFA_SIGNALING_VIA_NFKB-0.439
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.438
- IL2_STAT5_SIGNALING-0.408
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1471943 | GTEX | — | 0.990 |
| 2 | SRR1323106 | GTEX | — | 0.984 |
| 3 | SRR821626 | GTEX | — | 0.980 |
| 4 | SRR1084842 | GTEX | — | 0.974 |
| 5 | SRR1354446 | GTEX | — | 0.970 |
| 6 | SRR1317344 | GTEX | — | 0.969 |
| 7 | SRR662233 | GTEX | — | 0.969 |
| 8 | SRR1360563 | GTEX | — | 0.968 |
| 9 | SRR820623 | GTEX | — | 0.965 |
| 10 | SRR1408208 | GTEX | — | 0.963 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.388 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.271 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.186 | Remibrutinib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.136 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.126 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.103 | Cobimetinib | — uncovered |
| PROTEIN_SECRETION | 0.102 | Remibrutinib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.055 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.048 | Temsirolimus | — uncovered |
| UV_RESPONSE_DN | 0.022 | Inavolisib | — uncovered |