MNG1071
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.504
- CHOLESTEROL_HOMEOSTASIS+0.417
- ANDROGEN_RESPONSE+0.409
- TGF_BETA_SIGNALING+0.374
- MITOTIC_SPINDLE+0.362
- HEME_METABOLISM+0.335
- MTORC1_SIGNALING+0.329
- ADIPOGENESIS+0.310
- PI3K_AKT_MTOR_SIGNALING+0.307
- PEROXISOME+0.302
Top 10 suppressed
- MYC_TARGETS_V2-0.315
- ALLOGRAFT_REJECTION-0.280
- IL6_JAK_STAT3_SIGNALING-0.257
- PANCREAS_BETA_CELLS-0.216
- INFLAMMATORY_RESPONSE-0.193
- P53_PATHWAY-0.173
- INTERFERON_ALPHA_RESPONSE-0.168
- INTERFERON_GAMMA_RESPONSE-0.167
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.159
- KRAS_SIGNALING_DN-0.145
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-BH-A0BS-01A-11R-A12P-07 | — | B | 0.851 |
| 2 | MNG1056 | — | — | 0.786 |
| 3 | MNG1026 | — | — | 0.782 |
| 4 | C138638F-C6CB-439B-BFF0-CF097E0B421E | — | — | 0.775 |
| 5 | MNG1034 | — | — | 0.769 |
| 6 | TCGA-4Z-AA7Y-01A-11R-A39I-07 | — | — | 0.764 |
| 7 | MNG1193 | — | — | 0.757 |
| 8 | 387C53ED-A9ED-481F-87D9-87090B690E0E | — | — | 0.747 |
| 9 | 3DC38276-A6D2-49C6-8F54-3F50F6BFAD0C | — | — | 0.746 |
| 10 | 1E2D87A6-48B8-47FA-A801-AFEA7E01E829 | — | — | 0.741 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 34 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.504 | Remibrutinib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.417 | Remibrutinib | — uncovered |
| ANDROGEN_RESPONSE | 0.409 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.374 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.362 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.335 | Temsirolimus | — uncovered |
| MTORC1_SIGNALING | 0.329 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.310 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.307 | Inavolisib | — uncovered |
| PEROXISOME | 0.302 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.263 | Remibrutinib | — uncovered |
| UV_RESPONSE_DN | 0.250 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.248 | Temsirolimus | — uncovered |
| FATTY_ACID_METABOLISM | 0.248 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.235 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.187 | Inavolisib | — uncovered |
| GLYCOLYSIS | 0.187 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.160 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.154 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.151 | Idelalisib | — uncovered |