SRR1370619
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.308
- SPERMATOGENESIS+0.260
- KRAS_SIGNALING_DN+0.259
- HEDGEHOG_SIGNALING+0.186
- MYOGENESIS+0.043
- PANCREAS_BETA_CELLS-0.018
- ESTROGEN_RESPONSE_EARLY-0.075
- ESTROGEN_RESPONSE_LATE-0.100
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.125
- APICAL_SURFACE-0.127
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.614
- INTERFERON_GAMMA_RESPONSE-0.547
- IL6_JAK_STAT3_SIGNALING-0.496
- TNFA_SIGNALING_VIA_NFKB-0.435
- INFLAMMATORY_RESPONSE-0.425
- CHOLESTEROL_HOMEOSTASIS-0.410
- NOTCH_SIGNALING-0.405
- IL2_STAT5_SIGNALING-0.397
- APOPTOSIS-0.396
- ALLOGRAFT_REJECTION-0.383
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1335651 | GTEX | — | 0.978 |
| 2 | SRR1474065 | GTEX | — | 0.976 |
| 3 | SRR1485892 | GTEX | — | 0.972 |
| 4 | SRR1333741 | GTEX | — | 0.968 |
| 5 | SRR1477197 | GTEX | — | 0.968 |
| 6 | SRR1477634 | GTEX | — | 0.967 |
| 7 | SRR660626 | GTEX | — | 0.965 |
| 8 | SRR1367870 | GTEX | — | 0.964 |
| 9 | SRR1359388 | GTEX | — | 0.963 |
| 10 | SRR1481216 | GTEX | — | 0.963 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.308 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.260 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.259 | Remibrutinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.186 | Inavolisib | — uncovered |
| MYOGENESIS | 0.043 | Inavolisib | — uncovered |