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SRR1359388

GTEX

fc4f865a-3d88-5ae4-808a-8af5a257ba38

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
GTEX
cancer_type_detailed
subtype
cancer_type
GTEX
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • SPERMATOGENESIS+0.312
  • OXIDATIVE_PHOSPHORYLATION+0.171
  • KRAS_SIGNALING_DN+0.163
  • HEDGEHOG_SIGNALING+0.136
  • MYOGENESIS+0.001
  • UV_RESPONSE_DN-0.033
  • BILE_ACID_METABOLISM-0.044
  • APICAL_SURFACE-0.064
  • HEME_METABOLISM-0.074
  • FATTY_ACID_METABOLISM-0.087

Top 10 suppressed

  • IL6_JAK_STAT3_SIGNALING-0.591
  • INTERFERON_ALPHA_RESPONSE-0.581
  • INTERFERON_GAMMA_RESPONSE-0.538
  • TNFA_SIGNALING_VIA_NFKB-0.521
  • ALLOGRAFT_REJECTION-0.483
  • MYC_TARGETS_V1-0.463
  • INFLAMMATORY_RESPONSE-0.453
  • E2F_TARGETS-0.424
  • G2M_CHECKPOINT-0.418
  • ANGIOGENESIS-0.416

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR1477197
brain-umap@2
GTEX0.975
2SRR1335651
brain-umap@2
GTEX0.975
3SRR1477634
brain-umap@2
GTEX0.974
4SRR1474065
brain-umap@2
GTEX0.971
5SRR1367870
brain-umap@2
GTEX0.970
6SRR1465356
brain-umap@2
GTEX0.969
7SRR1070986
brain-umap@2
GTEX0.966
8SRR1370619
brain-umap@2
GTEX0.963
9SRR1397094
brain-umap@2
GTEX0.957
10SRR1487107
brain-umap@2
GTEX0.957

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 5 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
SPERMATOGENESIS0.312Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.171Remibrutinib— uncovered
KRAS_SIGNALING_DN0.163Remibrutinib— uncovered
HEDGEHOG_SIGNALING0.136Inavolisib— uncovered
MYOGENESIS0.001Inavolisib— uncovered