SRR1474065
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.318
- HEDGEHOG_SIGNALING+0.228
- KRAS_SIGNALING_DN+0.222
- SPERMATOGENESIS+0.193
- MYOGENESIS-0.009
- UV_RESPONSE_DN-0.028
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.043
- ESTROGEN_RESPONSE_EARLY-0.059
- PANCREAS_BETA_CELLS-0.065
- FATTY_ACID_METABOLISM-0.072
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.599
- INTERFERON_GAMMA_RESPONSE-0.511
- IL6_JAK_STAT3_SIGNALING-0.453
- ANGIOGENESIS-0.441
- INFLAMMATORY_RESPONSE-0.406
- CHOLESTEROL_HOMEOSTASIS-0.404
- G2M_CHECKPOINT-0.370
- E2F_TARGETS-0.368
- COAGULATION-0.351
- APOPTOSIS-0.334
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1370619 | GTEX | — | 0.976 |
| 2 | SRR1322555 | GTEX | — | 0.975 |
| 3 | SRR1477634 | GTEX | — | 0.974 |
| 4 | SRR1335651 | GTEX | — | 0.973 |
| 5 | SRR1465356 | GTEX | — | 0.971 |
| 6 | SRR1359388 | GTEX | — | 0.971 |
| 7 | SRR1359192 | GTEX | — | 0.964 |
| 8 | SRR1376597 | GTEX | — | 0.961 |
| 9 | SRR600560 | GTEX | — | 0.961 |
| 10 | SRR1367870 | GTEX | — | 0.961 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 4 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.318 | Remibrutinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.228 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.222 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.193 | Inavolisib | — uncovered |