SRR602169
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.313
- HEME_METABOLISM+0.156
- FATTY_ACID_METABOLISM+0.134
- MYOGENESIS+0.103
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.089
- APICAL_JUNCTION+0.084
- SPERMATOGENESIS+0.072
- PROTEIN_SECRETION+0.070
- PEROXISOME+0.039
- BILE_ACID_METABOLISM+0.034
Top 10 suppressed
- INTERFERON_GAMMA_RESPONSE-0.559
- IL6_JAK_STAT3_SIGNALING-0.550
- TNFA_SIGNALING_VIA_NFKB-0.548
- INTERFERON_ALPHA_RESPONSE-0.540
- ALLOGRAFT_REJECTION-0.517
- E2F_TARGETS-0.486
- INFLAMMATORY_RESPONSE-0.442
- G2M_CHECKPOINT-0.407
- IL2_STAT5_SIGNALING-0.383
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.367
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR602728 | GTEX | — | 0.943 |
| 2 | SRR600445 | GTEX | — | 0.939 |
| 3 | SRR1336660 | GTEX | — | 0.937 |
| 4 | SRR602704 | GTEX | — | 0.935 |
| 5 | SRR1328895 | GTEX | — | 0.934 |
| 6 | SRR821549 | GTEX | — | 0.932 |
| 7 | SRR1447693 | GTEX | — | 0.932 |
| 8 | SRR1453341 | GTEX | — | 0.932 |
| 9 | SRR821626 | GTEX | — | 0.931 |
| 10 | SRR1341365 | GTEX | — | 0.930 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 12 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.313 | Remibrutinib | — uncovered |
| HEME_METABOLISM | 0.156 | Temsirolimus | — uncovered |
| FATTY_ACID_METABOLISM | 0.134 | Inavolisib | — uncovered |
| MYOGENESIS | 0.103 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.089 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.084 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.072 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.070 | Remibrutinib | — uncovered |
| PEROXISOME | 0.039 | Idelalisib | — uncovered |
| BILE_ACID_METABOLISM | 0.034 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.032 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.028 | Remibrutinib | — uncovered |