df6771b0-4b6c-4565-a2f1-4d919f8d68c9
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYC_TARGETS_V2+0.400
- OXIDATIVE_PHOSPHORYLATION+0.300
- UNFOLDED_PROTEIN_RESPONSE+0.300
- DNA_REPAIR+0.200
- PANCREAS_BETA_CELLS+0.200
- MYC_TARGETS_V1+0.100
- NOTCH_SIGNALING+0.100
- FATTY_ACID_METABOLISM+0.000
- PROTEIN_SECRETION+0.000
- SPERMATOGENESIS+0.000
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.600
- INTERFERON_GAMMA_RESPONSE-0.600
- ALLOGRAFT_REJECTION-0.500
- IL2_STAT5_SIGNALING-0.500
- IL6_JAK_STAT3_SIGNALING-0.500
- INFLAMMATORY_RESPONSE-0.500
- TNFA_SIGNALING_VIA_NFKB-0.500
- APOPTOSIS-0.400
- CHOLESTEROL_HOMEOSTASIS-0.400
- COMPLEMENT-0.400
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | R16 | — | — | 0.903 |
| 2 | ERR2208948 | — | — | 0.891 |
| 3 | TCGA-KU-A66S-01A-21R-A30B-07 | — | — | 0.887 |
| 4 | GSM5359423 | — | — | 0.886 |
| 5 | SRR25617882 | — | B | 0.874 |
| 6 | SRR4296068 | — | cohortA1 | 0.869 |
| 7 | SRR5088853 | — | — | 0.866 |
| 8 | s0095168 | — | — | 0.865 |
| 9 | SRR1797244 | — | cohortSC | 0.863 |
| 10 | s_150324_3a | EPN | Posterior Fossa EPN | 0.861 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V2 | 0.400 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.300 | Remibrutinib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.300 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.200 | Idelalisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.200 | Cobimetinib | — uncovered |
| MYC_TARGETS_V1 | 0.100 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.100 | Inavolisib | — uncovered |