Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
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TCGA-KU-A66S-01A-21R-A30B-07

1348e3fa-62f0-5462-9050-04dc07a5f261

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
0.092694064
sex
female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • MYC_TARGETS_V1+0.310
  • OXIDATIVE_PHOSPHORYLATION+0.300
  • PANCREAS_BETA_CELLS+0.290
  • SPERMATOGENESIS+0.290
  • MYC_TARGETS_V2+0.230
  • DNA_REPAIR+0.220
  • WNT_BETA_CATENIN_SIGNALING+0.100
  • BILE_ACID_METABOLISM+0.090
  • E2F_TARGETS-0.020
  • FATTY_ACID_METABOLISM-0.050

Top 10 suppressed

  • INTERFERON_ALPHA_RESPONSE-0.550
  • IL6_JAK_STAT3_SIGNALING-0.540
  • INTERFERON_GAMMA_RESPONSE-0.510
  • INFLAMMATORY_RESPONSE-0.490
  • TNFA_SIGNALING_VIA_NFKB-0.460
  • APICAL_SURFACE-0.440
  • HYPOXIA-0.420
  • UV_RESPONSE_DN-0.420
  • APICAL_JUNCTION-0.400
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.400

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1264656b8-d45c-4f5c-a431-366c566296fe
melanoma-umap@29
0.932
2TCGA-DK-AA75-01A-11R-A39I-07
bladder-landscape@3
0.901
3SRR5088853
melanoma-umap@29
0.891
4TCGA-E5-A4U1-01A-11R-A31N-07
bladder-landscape@3
0.890
5df6771b0-4b6c-4565-a2f1-4d919f8d68c9
melanoma-umap@29
0.887
6SRR4296068
lung-landscapes@6
cohortA10.886
7TCGA-QK-A8Z7-01A-11R-A39I-07
head-neck@1
0.873
8R16
bladder-landscape@3
0.872
9BS_V9HVBBDW
brain-umap@2
medulloblastoma0.871
10MNG887
mng-umap@100
0.871

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 8 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V10.310Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.300Remibrutinib— uncovered
PANCREAS_BETA_CELLS0.290Cobimetinib— uncovered
SPERMATOGENESIS0.290Inavolisib— uncovered
MYC_TARGETS_V20.230Idelalisib— uncovered
DNA_REPAIR0.220Idelalisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.100Inavolisib— uncovered
BILE_ACID_METABOLISM0.090Inavolisib— uncovered