GSM5359423
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYC_TARGETS_V2+0.500
- MYC_TARGETS_V1+0.310
- UNFOLDED_PROTEIN_RESPONSE+0.180
- OXIDATIVE_PHOSPHORYLATION+0.120
- DNA_REPAIR+0.060
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.020
- GLYCOLYSIS+0.000
- ANDROGEN_RESPONSE-0.030
- KRAS_SIGNALING_DN-0.040
- PEROXISOME-0.060
Top 10 suppressed
- IL6_JAK_STAT3_SIGNALING-0.540
- INTERFERON_GAMMA_RESPONSE-0.530
- INTERFERON_ALPHA_RESPONSE-0.520
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.490
- ALLOGRAFT_REJECTION-0.470
- COMPLEMENT-0.470
- INFLAMMATORY_RESPONSE-0.460
- TNFA_SIGNALING_VIA_NFKB-0.460
- APOPTOSIS-0.420
- IL2_STAT5_SIGNALING-0.410
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
4 twins match this tumor's tissue · 6 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | R16 | — | — | 0.924 |
| 2 | SRR25617882 | — | B | 0.913 |
| 3 | SRR1441141 | GTEX | — | 0.893 |
| 4 | SRR1477385 | GTEX | — | 0.892 |
| 5 | SRR5088853 | — | — | 0.891 |
| 6 | SRR1357413 | GTEX | — | 0.887 |
| 7 | SRR1472621 | GTEX | — | 0.887 |
| 8 | df6771b0-4b6c-4565-a2f1-4d919f8d68c9 | — | — | 0.886 |
| 9 | SRR1458422 | GTEX | — | 0.884 |
| 10 | SRR1441118 | GTEX | — | 0.882 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 6 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V2 | 0.500 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.310 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.180 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.120 | Remibrutinib | — uncovered |
| DNA_REPAIR | 0.060 | Idelalisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.020 | Inavolisib | — uncovered |