SRR1443824
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- SPERMATOGENESIS+0.306
- KRAS_SIGNALING_DN+0.304
- HEDGEHOG_SIGNALING+0.245
- MYOGENESIS+0.142
- PANCREAS_BETA_CELLS+0.137
- BILE_ACID_METABOLISM+0.104
- UV_RESPONSE_DN+0.077
- APICAL_SURFACE+0.030
- ESTROGEN_RESPONSE_LATE+0.024
- XENOBIOTIC_METABOLISM+0.004
Top 10 suppressed
- MYC_TARGETS_V1-0.560
- MYC_TARGETS_V2-0.552
- DNA_REPAIR-0.477
- INTERFERON_ALPHA_RESPONSE-0.469
- UNFOLDED_PROTEIN_RESPONSE-0.458
- MTORC1_SIGNALING-0.445
- CHOLESTEROL_HOMEOSTASIS-0.431
- E2F_TARGETS-0.431
- TNFA_SIGNALING_VIA_NFKB-0.420
- G2M_CHECKPOINT-0.417
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1432343 | GTEX | — | 0.966 |
| 2 | SRR1406561 | GTEX | — | 0.956 |
| 3 | SRR1325986 | GTEX | — | 0.953 |
| 4 | SRR1466069 | GTEX | — | 0.950 |
| 5 | SRR657891 | GTEX | — | 0.946 |
| 6 | SRR1315269 | GTEX | — | 0.945 |
| 7 | SRR1402454 | GTEX | — | 0.944 |
| 8 | SRR1417505 | GTEX | — | 0.943 |
| 9 | SRR1403050 | GTEX | — | 0.942 |
| 10 | SRR1336357 | GTEX | — | 0.941 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| SPERMATOGENESIS | 0.306 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.304 | Remibrutinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.245 | Inavolisib | — uncovered |
| MYOGENESIS | 0.142 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.137 | Cobimetinib | — uncovered |
| BILE_ACID_METABOLISM | 0.104 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.077 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.030 | Temsirolimus | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.024 | Idelalisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.004 | Inavolisib | — uncovered |