SRR1403050
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.372
- SPERMATOGENESIS+0.363
- PANCREAS_BETA_CELLS+0.208
- HEDGEHOG_SIGNALING+0.092
- UV_RESPONSE_DN+0.072
- MYOGENESIS+0.044
- ESTROGEN_RESPONSE_LATE-0.018
- OXIDATIVE_PHOSPHORYLATION-0.025
- ESTROGEN_RESPONSE_EARLY-0.027
- BILE_ACID_METABOLISM-0.030
Top 10 suppressed
- CHOLESTEROL_HOMEOSTASIS-0.548
- INTERFERON_ALPHA_RESPONSE-0.534
- MYC_TARGETS_V1-0.518
- IL6_JAK_STAT3_SIGNALING-0.463
- DNA_REPAIR-0.456
- UNFOLDED_PROTEIN_RESPONSE-0.453
- E2F_TARGETS-0.452
- MTORC1_SIGNALING-0.440
- INTERFERON_GAMMA_RESPONSE-0.435
- G2M_CHECKPOINT-0.424
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1487107 | GTEX | — | 0.978 |
| 2 | SRR1403831 | GTEX | — | 0.976 |
| 3 | SRR1357021 | GTEX | — | 0.973 |
| 4 | SRR1336357 | GTEX | — | 0.968 |
| 5 | SRR1432343 | GTEX | — | 0.967 |
| 6 | SRR1406561 | GTEX | — | 0.965 |
| 7 | SRR1476676 | GTEX | — | 0.960 |
| 8 | SRR1413625 | GTEX | — | 0.955 |
| 9 | SRR1466850 | GTEX | — | 0.955 |
| 10 | SRR1361567 | GTEX | — | 0.953 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 6 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.372 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.363 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.208 | Cobimetinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.092 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.072 | Inavolisib | — uncovered |
| MYOGENESIS | 0.044 | Inavolisib | — uncovered |