SRR1486560
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- SPERMATOGENESIS+0.411
- KRAS_SIGNALING_DN+0.393
- MYOGENESIS+0.271
- ESTROGEN_RESPONSE_EARLY+0.142
- HEDGEHOG_SIGNALING+0.133
- OXIDATIVE_PHOSPHORYLATION+0.131
- BILE_ACID_METABOLISM+0.128
- ESTROGEN_RESPONSE_LATE+0.117
- PANCREAS_BETA_CELLS+0.066
- APICAL_JUNCTION+0.034
Top 10 suppressed
- MYC_TARGETS_V1-0.527
- INTERFERON_ALPHA_RESPONSE-0.507
- E2F_TARGETS-0.489
- G2M_CHECKPOINT-0.472
- MYC_TARGETS_V2-0.459
- UNFOLDED_PROTEIN_RESPONSE-0.438
- PROTEIN_SECRETION-0.437
- IL6_JAK_STAT3_SIGNALING-0.428
- INTERFERON_GAMMA_RESPONSE-0.425
- MTORC1_SIGNALING-0.419
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1414833 | GTEX | — | 0.975 |
| 2 | SRR1445347 | GTEX | — | 0.959 |
| 3 | SRR1456950 | GTEX | — | 0.954 |
| 4 | SRR1413625 | GTEX | — | 0.948 |
| 5 | SRR1337074 | GTEX | — | 0.947 |
| 6 | SRR1379450 | GTEX | — | 0.947 |
| 7 | SRR598428 | GTEX | — | 0.946 |
| 8 | SRR816721 | GTEX | — | 0.945 |
| 9 | SRR1329377 | GTEX | — | 0.944 |
| 10 | SRR818396 | GTEX | — | 0.941 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| SPERMATOGENESIS | 0.411 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.393 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.271 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.142 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.133 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.131 | Remibrutinib | — uncovered |
| BILE_ACID_METABOLISM | 0.128 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.117 | Idelalisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.066 | Cobimetinib | — uncovered |
| APICAL_JUNCTION | 0.034 | Inavolisib | — uncovered |