SRR1456950
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.433
- PANCREAS_BETA_CELLS+0.333
- SPERMATOGENESIS+0.253
- MYOGENESIS+0.246
- HEDGEHOG_SIGNALING+0.207
- ESTROGEN_RESPONSE_LATE+0.100
- OXIDATIVE_PHOSPHORYLATION+0.074
- ESTROGEN_RESPONSE_EARLY+0.070
- APICAL_SURFACE+0.018
- UV_RESPONSE_DN-0.037
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.502
- MYC_TARGETS_V2-0.477
- MTORC1_SIGNALING-0.473
- E2F_TARGETS-0.466
- PROTEIN_SECRETION-0.466
- G2M_CHECKPOINT-0.457
- CHOLESTEROL_HOMEOSTASIS-0.454
- MYC_TARGETS_V1-0.444
- UNFOLDED_PROTEIN_RESPONSE-0.438
- INTERFERON_GAMMA_RESPONSE-0.421
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1406561 | GTEX | — | 0.967 |
| 2 | SRR1486560 | GTEX | — | 0.954 |
| 3 | SRR1403050 | GTEX | — | 0.953 |
| 4 | SRR1337074 | GTEX | — | 0.951 |
| 5 | SRR1365987 | GTEX | — | 0.948 |
| 6 | SRR1357021 | GTEX | — | 0.948 |
| 7 | SRR1432343 | GTEX | — | 0.947 |
| 8 | SRR1336357 | GTEX | — | 0.945 |
| 9 | SRR1414833 | GTEX | — | 0.945 |
| 10 | SRR1467882 | GTEX | — | 0.944 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.433 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.333 | Cobimetinib | — uncovered |
| SPERMATOGENESIS | 0.253 | Inavolisib | — uncovered |
| MYOGENESIS | 0.246 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.207 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.100 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.074 | Remibrutinib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.070 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.018 | Temsirolimus | — uncovered |