Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
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R10

0b840448-9e65-5c18-bb0b-30ed0db67ee3

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
124
sex
Male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR12202456
bladder-landscape@3
0.716
2DRR168519
bladder-landscape@3
0.703
3TCGA-ZF-A9R5-01A-12R-A42T-07
bladder-landscape@3
0.697
4ME1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
ccle-aml@v2024.1
AML0.694
5ERR2278869
head-neck@1
0.689
6SRR5088854
melanoma-umap@29
0.676
7TCGA-E7-A678-01A-11R-A30C-07
bladder-landscape@3
0.674
8TCGA-MT-A67A-01A-11R-A30B-07
head-neck@1
0.671
9TCGA-XF-AAN1-01A-31R-A42T-07
bladder-landscape@3
0.671
10MNG652
mng-umap@100
0.669

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 13 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.310Inavolisib— uncovered
MYC_TARGETS_V20.280Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.250Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.120Remibrutinib— uncovered
APICAL_SURFACE0.090Temsirolimus— uncovered
P53_PATHWAY0.070Idelalisib— uncovered
MYC_TARGETS_V10.060Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.050Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.050Inavolisib— uncovered
NOTCH_SIGNALING0.040Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.030Remibrutinib— uncovered
DNA_REPAIR0.020Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.010Inavolisib— uncovered