MNG200
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MITOTIC_SPINDLE+0.306
- INTERFERON_GAMMA_RESPONSE+0.271
- INTERFERON_ALPHA_RESPONSE+0.262
- ALLOGRAFT_REJECTION+0.202
- UV_RESPONSE_DN+0.187
- DNA_REPAIR+0.148
- PI3K_AKT_MTOR_SIGNALING+0.112
- IL6_JAK_STAT3_SIGNALING+0.095
- WNT_BETA_CATENIN_SIGNALING+0.089
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.069
Top 10 suppressed
- MTORC1_SIGNALING-0.380
- MYC_TARGETS_V1-0.365
- ANGIOGENESIS-0.316
- CHOLESTEROL_HOMEOSTASIS-0.303
- ESTROGEN_RESPONSE_LATE-0.301
- TNFA_SIGNALING_VIA_NFKB-0.270
- PANCREAS_BETA_CELLS-0.269
- COAGULATION-0.264
- MYC_TARGETS_V2-0.263
- UNFOLDED_PROTEIN_RESPONSE-0.261
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | aMVAC.P_002_TURBT_S219 | — | — | 0.838 |
| 2 | MNG911 | — | — | 0.810 |
| 3 | MNG881 | — | — | 0.798 |
| 4 | MNG876 | — | — | 0.778 |
| 5 | MNG1006 | — | — | 0.761 |
| 6 | MNG54 | — | — | 0.759 |
| 7 | GSM5359433 | — | — | 0.746 |
| 8 | SJEPD031385_D1.RNA-Seq | EPN | EPN Tumor | 0.745 |
| 9 | MNG696 | — | — | 0.743 |
| 10 | MNG516 | — | — | 0.741 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MITOTIC_SPINDLE | 0.306 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.271 | Idelalisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.262 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.202 | Idelalisib | — uncovered |
| UV_RESPONSE_DN | 0.187 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.148 | Idelalisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.112 | Inavolisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.095 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.089 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.069 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.040 | Inavolisib | — uncovered |