Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
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MNG911

5c1e61d3-9279-5f51-b9da-621f939abbcd

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MNG881
mng-umap@100
0.859
2MNG60
mng-umap@100
0.836
3MNG882
mng-umap@100
0.817
4MBCProject_5856_T0B_RNA
breast-umap@18
A0.814
5s0122234
melanoma-umap@29
0.811
6MNG200
mng-umap@100
0.810
7ERR2208971
melanoma-umap@29
0.809
8SRR1313120
breast-umap@18
A0.807
9TCGA-60-2721-01A-01R-0851-07
lung-landscapes@6
cohortSQ10.806
10ERR2208899
melanoma-umap@29
0.805

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 10 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ALLOGRAFT_REJECTION0.211Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.190Inavolisib— uncovered
UV_RESPONSE_DN0.133Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.113Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.085Idelalisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.081Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.056Inavolisib— uncovered
MYOGENESIS0.056Inavolisib— uncovered
KRAS_SIGNALING_DN0.014Remibrutinib— uncovered
TGF_BETA_SIGNALING0.011Inavolisib— uncovered