Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · breast-umap@18

SRR8518252

— · A

0d87de04-9406-5389-b509-7521acab40ab

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
A
subtype
A

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR8613745
breast-umap@18
—A0.884
2C3N-02087
lung-landscapes@6
—cohortA10.882
3ERR2208974
melanoma-umap@29
——0.875
4R209
bladder-landscape@3
——0.870
5X16125ffc.4138.408e.9573.cd6c960504cf
lung-landscapes@6
—cohortA10.866
6MNG380
mng-umap@100
——0.864
7SRR8518236
breast-umap@18
—A0.859
8TCGA-ZF-A9RD-01A-11R-A42T-07
bladder-landscape@3
——0.853
9C3L-00913
lung-landscapes@6
—cohortA40.848
10MBCProject_1334_T2_RNA
breast-umap@18
—C0.846

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 39 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ALLOGRAFT_REJECTION0.570Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.530Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.490Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.480Idelalisib— uncovered
COMPLEMENT0.470Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.430Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.420Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.410Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.400Inavolisib— uncovered
IL2_STAT5_SIGNALING0.380Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.360Remibrutinib— uncovered
COAGULATION0.350Binimetinib— uncovered
APOPTOSIS0.340Idelalisib— uncovered
E2F_TARGETS0.340Inavolisib— uncovered
PROTEIN_SECRETION0.340Remibrutinib— uncovered
G2M_CHECKPOINT0.320Inavolisib— uncovered
KRAS_SIGNALING_UP0.260Inavolisib— uncovered
PANCREAS_BETA_CELLS0.250Cobimetinib— uncovered
MITOTIC_SPINDLE0.230Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.230Inavolisib— uncovered