Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

X16125ffc.4138.408e.9573.cd6c960504cf

· cohortA1

0e1a7c60-2d13-55df-b52d-c7945f4ace56

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
cohortA1
subtype
cohortA1
age_years
83

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1DF145DF3-D7FD-48C9-ADC8-0B8618DC65A8
brain-umap@2
0.902
2SRR6013499
lung-landscapes@6
cohortA10.902
3SRR6013500
lung-landscapes@6
cohortA10.901
4TCGA-ZF-A9RD-01A-11R-A42T-07
bladder-landscape@3
0.900
53E499D12-B08A-491C-98C6-19EA420BDC99
brain-umap@2
0.900
6ERR2208974
melanoma-umap@29
0.898
7A43D720D-0CA3-48CF-ADC7-5AC72BD5EEA9
brain-umap@2
0.887
8c59a00cb-985f-41b6-b66b-decefb8c9f66
melanoma-umap@29
0.887
9D06FFD0C-80D4-413D-9C83-62D9C163EDAB
brain-umap@2
0.886
108f1213be-da41-4cd6-97b2-f9fce1ea00ff
colon-landscapes@1
0.886

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 40 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.550Inavolisib— uncovered
E2F_TARGETS0.510Inavolisib— uncovered
ALLOGRAFT_REJECTION0.500Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.470Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.450Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.430Remibrutinib— uncovered
COMPLEMENT0.410Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.410Idelalisib— uncovered
MYC_TARGETS_V10.410Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.390Inavolisib— uncovered
MTORC1_SIGNALING0.380Inavolisib— uncovered
G2M_CHECKPOINT0.360Inavolisib— uncovered
DNA_REPAIR0.330Idelalisib— uncovered
KRAS_SIGNALING_UP0.330Inavolisib— uncovered
HYPOXIA0.320Idelalisib— uncovered
PROTEIN_SECRETION0.300Remibrutinib— uncovered
IL2_STAT5_SIGNALING0.290Idelalisib— uncovered
COAGULATION0.270Binimetinib— uncovered
ADIPOGENESIS0.260Inavolisib— uncovered
APOPTOSIS0.260Idelalisib— uncovered