Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · mng-umap@100

MNG804

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0edfbec2-5017-5a2a-b441-c2ee5d1250ad

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • ALLOGRAFT_REJECTION+0.412
  • REACTIVE_OXYGEN_SPECIES_PATHWAY+0.271
  • INTERFERON_GAMMA_RESPONSE+0.256
  • PI3K_AKT_MTOR_SIGNALING+0.256
  • IL6_JAK_STAT3_SIGNALING+0.222
  • OXIDATIVE_PHOSPHORYLATION+0.217
  • INTERFERON_ALPHA_RESPONSE+0.211
  • ADIPOGENESIS+0.183
  • COMPLEMENT+0.169
  • PROTEIN_SECRETION+0.121

Top 10 suppressed

  • G2M_CHECKPOINT-0.403
  • ANGIOGENESIS-0.391
  • E2F_TARGETS-0.389
  • CHOLESTEROL_HOMEOSTASIS-0.369
  • ANDROGEN_RESPONSE-0.283
  • ESTROGEN_RESPONSE_LATE-0.281
  • MTORC1_SIGNALING-0.275
  • GLYCOLYSIS-0.241
  • HYPOXIA-0.230
  • MYC_TARGETS_V1-0.226

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MNG351
mng-umap@100
——0.820
2MNG433
mng-umap@100
——0.759
3MNG73
mng-umap@100
——0.756
4MNG815
mng-umap@100
——0.740
5MNG980
mng-umap@100
——0.734
6X3cd3fbb2.8eb1.4fd0.ae5f.c940ae00e311
lung-landscapes@6
—cohortA10.713
7SRR8942946
bladder-landscape@3
——0.710
8TCGA-78-7539-01A-11R-2066-07
lung-landscapes@6
—cohortA10.699
9MNG776
mng-umap@100
——0.699
10TCGA-AC-A6IX-06A-11R-A32P-07
breast-umap@18
—D0.698

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 19 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ALLOGRAFT_REJECTION0.412Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.271Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.256Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.256Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.222Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.217Remibrutinib— uncovered
INTERFERON_ALPHA_RESPONSE0.211Inavolisib— uncovered
ADIPOGENESIS0.183Inavolisib— uncovered
COMPLEMENT0.169Inavolisib— uncovered
PROTEIN_SECRETION0.121Remibrutinib— uncovered
INFLAMMATORY_RESPONSE0.105Idelalisib— uncovered
HEDGEHOG_SIGNALING0.096Inavolisib— uncovered
NOTCH_SIGNALING0.088Inavolisib— uncovered
FATTY_ACID_METABOLISM0.069Inavolisib— uncovered
KRAS_SIGNALING_UP0.061Inavolisib— uncovered
PEROXISOME0.034Idelalisib— uncovered
APOPTOSIS0.024Idelalisib— uncovered
P53_PATHWAY0.024Idelalisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.005Inavolisib— uncovered