MNG73
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.365
- ALLOGRAFT_REJECTION+0.360
- INTERFERON_GAMMA_RESPONSE+0.359
- DNA_REPAIR+0.201
- IL6_JAK_STAT3_SIGNALING+0.147
- OXIDATIVE_PHOSPHORYLATION+0.096
- FATTY_ACID_METABOLISM+0.069
- ADIPOGENESIS+0.056
- INFLAMMATORY_RESPONSE+0.035
- P53_PATHWAY+0.015
Top 10 suppressed
- ANGIOGENESIS-0.501
- G2M_CHECKPOINT-0.433
- MTORC1_SIGNALING-0.383
- MITOTIC_SPINDLE-0.360
- ESTROGEN_RESPONSE_LATE-0.346
- CHOLESTEROL_HOMEOSTASIS-0.330
- TNFA_SIGNALING_VIA_NFKB-0.322
- ESTROGEN_RESPONSE_EARLY-0.310
- E2F_TARGETS-0.294
- NOTCH_SIGNALING-0.261
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG433 | — | — | 0.918 |
| 2 | TCGA-CV-A461-01A-41R-A266-07 | — | — | 0.826 |
| 3 | MNG881 | — | — | 0.794 |
| 4 | DRR168519 | — | — | 0.786 |
| 5 | MNG351 | — | — | 0.782 |
| 6 | ERR4976617 | — | D | 0.781 |
| 7 | MNG516 | — | — | 0.776 |
| 8 | MNG61 | — | — | 0.775 |
| 9 | SJEPD027_D.RNA-Seq | EPN | Posterior Fossa EPN | 0.773 |
| 10 | MNG911 | — | — | 0.769 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.365 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.360 | Idelalisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.359 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.201 | Idelalisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.147 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.096 | Remibrutinib | — uncovered |
| FATTY_ACID_METABOLISM | 0.069 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.056 | Inavolisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.035 | Idelalisib | — uncovered |
| P53_PATHWAY | 0.015 | Idelalisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.006 | Inavolisib | — uncovered |
| COMPLEMENT | 0.005 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.005 | Cobimetinib | — uncovered |