MNG351
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG804 | — | — | 0.820 |
| 2 | MNG433 | — | — | 0.800 |
| 3 | X3cd3fbb2.8eb1.4fd0.ae5f.c940ae00e311 | — | cohortA1 | 0.788 |
| 4 | MNG73 | — | — | 0.782 |
| 5 | SRR8943026 | — | — | 0.773 |
| 6 | TCGA-OR-A5LN-01 | Adrenocortical Carcinoma | Adrenocortical Carcinoma, Usual Type | 0.750 |
| 7 | SRR27320680 | — | — | 0.748 |
| 8 | TCGA-78-7539-01A-11R-2066-07 | — | cohortA1 | 0.748 |
| 9 | SRR8526721 | — | cohortA1 | 0.736 |
| 10 | EPT0525 | EPN | Posterior Fossa EPN | 0.732 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 21 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.641 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.501 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.422 | Remibrutinib | — uncovered |
| ALLOGRAFT_REJECTION | 0.366 | Idelalisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.300 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.256 | Idelalisib | — uncovered |
| PEROXISOME | 0.181 | Idelalisib | — uncovered |
| ADIPOGENESIS | 0.169 | Inavolisib | — uncovered |
| COMPLEMENT | 0.169 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.164 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.151 | Remibrutinib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.138 | Idelalisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.133 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.130 | Inavolisib | — uncovered |
| KRAS_SIGNALING_UP | 0.096 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.072 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.064 | Idelalisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.032 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.030 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.023 | Inavolisib | — uncovered |