8c7c9bb7-76e0-480c-a0de-bbf48fa398f4
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.300
- CHOLESTEROL_HOMEOSTASIS+0.100
- DNA_REPAIR+0.100
- HEME_METABOLISM+0.100
- PEROXISOME+0.100
- UNFOLDED_PROTEIN_RESPONSE+0.100
- ANDROGEN_RESPONSE+0.000
- BILE_ACID_METABOLISM+0.000
- FATTY_ACID_METABOLISM+0.000
- GLYCOLYSIS+0.000
Top 10 suppressed
- ALLOGRAFT_REJECTION-0.600
- INFLAMMATORY_RESPONSE-0.500
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.400
- IL6_JAK_STAT3_SIGNALING-0.400
- INTERFERON_GAMMA_RESPONSE-0.400
- KRAS_SIGNALING_UP-0.400
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.400
- APICAL_JUNCTION-0.300
- E2F_TARGETS-0.300
- IL2_STAT5_SIGNALING-0.300
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
6 twins match this tumor's tissue · 4 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1322163 | GTEX | — | 0.864 |
| 2 | MBCProject_0343_T1_RNA | — | B | 0.857 |
| 3 | TCGA-A7-A0DC-01A-11R-A00Z-07 | — | D | 0.848 |
| 4 | TCGA-G2-A3VY-01A-11R-A22U-07 | — | — | 0.846 |
| 5 | SRR612419 | GTEX | — | 0.845 |
| 6 | MDT-AP-0119 | Med | Medulloblastoma | 0.845 |
| 7 | aMVAC.P_001_TURBT_S217 | — | — | 0.843 |
| 8 | TCGA-D8-A1XC-01A-11R-A14D-07 | — | B | 0.843 |
| 9 | SRR1442356 | GTEX | — | 0.841 |
| 10 | SRR29022828 | — | B | 0.841 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 6 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.300 | Remibrutinib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.100 | Remibrutinib | — uncovered |
| DNA_REPAIR | 0.100 | Idelalisib | — uncovered |
| HEME_METABOLISM | 0.100 | Temsirolimus | — uncovered |
| PEROXISOME | 0.100 | Idelalisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.100 | Idelalisib | — uncovered |