SRR29022828
— · B
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- B
- subtype
- B
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- ESTROGEN_RESPONSE_EARLY+0.340
- ESTROGEN_RESPONSE_LATE+0.180
- PEROXISOME+0.160
- DNA_REPAIR+0.070
- SPERMATOGENESIS+0.060
- BILE_ACID_METABOLISM+0.050
- PROTEIN_SECRETION+0.040
- UNFOLDED_PROTEIN_RESPONSE+0.010
- HEME_METABOLISM+0.000
- MYC_TARGETS_V2-0.060
Top 10 suppressed
- ALLOGRAFT_REJECTION-0.630
- INTERFERON_GAMMA_RESPONSE-0.620
- TNFA_SIGNALING_VIA_NFKB-0.590
- INTERFERON_ALPHA_RESPONSE-0.580
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.570
- IL6_JAK_STAT3_SIGNALING-0.550
- INFLAMMATORY_RESPONSE-0.550
- ANGIOGENESIS-0.440
- COMPLEMENT-0.430
- KRAS_SIGNALING_UP-0.430
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-E2-A15G-01A-11R-A12D-07 | — | B | 0.915 |
| 2 | MBCProject_0343_T1_RNA | — | B | 0.902 |
| 3 | SRR25617889 | — | B | 0.901 |
| 4 | SRR35579848 | — | B | 0.900 |
| 5 | TCGA-A7-A0DC-01A-11R-A00Z-07 | — | D | 0.890 |
| 6 | SRR1398992 | GTEX | — | 0.889 |
| 7 | SRR1322163 | GTEX | — | 0.888 |
| 8 | a50c02ec-6ba9-4678-990d-6c74a8e9b7b5 | — | — | 0.884 |
| 9 | TCGA-G2-AA3F-01A-12R-A42T-07 | — | — | 0.883 |
| 10 | SRR1385036 | GTEX | — | 0.881 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| ESTROGEN_RESPONSE_EARLY | 0.340 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.180 | Idelalisib | — uncovered |
| PEROXISOME | 0.160 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.070 | Idelalisib | — uncovered |
| SPERMATOGENESIS | 0.060 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.050 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.040 | Remibrutinib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.010 | Idelalisib | — uncovered |