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SRR661179

GTEX

17d062ec-5834-548a-8eff-13b3854bf473

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
GTEX
cancer_type_detailed
subtype
cancer_type
GTEX
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • PANCREAS_BETA_CELLS+0.312
  • HEDGEHOG_SIGNALING+0.282
  • SPERMATOGENESIS+0.205
  • KRAS_SIGNALING_DN+0.074
  • MYOGENESIS+0.066
  • APICAL_JUNCTION-0.007
  • PROTEIN_SECRETION-0.039
  • APICAL_SURFACE-0.075
  • ESTROGEN_RESPONSE_LATE-0.078
  • PEROXISOME-0.087

Top 10 suppressed

  • TNFA_SIGNALING_VIA_NFKB-0.514
  • MYC_TARGETS_V1-0.469
  • TGF_BETA_SIGNALING-0.439
  • OXIDATIVE_PHOSPHORYLATION-0.411
  • G2M_CHECKPOINT-0.410
  • IL6_JAK_STAT3_SIGNALING-0.399
  • MYC_TARGETS_V2-0.392
  • DNA_REPAIR-0.391
  • E2F_TARGETS-0.387
  • UNFOLDED_PROTEIN_RESPONSE-0.383

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR1334717
brain-umap@2
GTEX0.967
2SRR1325986
brain-umap@2
GTEX0.938
3SRR1478032
brain-umap@2
GTEX0.937
4MNG700
mng-umap@100
0.936
5SRR1443713
brain-umap@2
GTEX0.932
6BS_3P20Q2C3
brain-umap@2
low-grade glioma0.926
7SRR1357021
brain-umap@2
GTEX0.925
8MNG1280
mng-umap@100
0.924
9BS_90B22NGP
brain-umap@2
ATRT0.924
10MNG226
mng-umap@100
0.923

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 5 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PANCREAS_BETA_CELLS0.312Cobimetinib— uncovered
HEDGEHOG_SIGNALING0.282Inavolisib— uncovered
SPERMATOGENESIS0.205Inavolisib— uncovered
KRAS_SIGNALING_DN0.074Remibrutinib— uncovered
MYOGENESIS0.066Inavolisib— uncovered