SRR1478032

GTEX

7f72f629-fc4f-52b1-b6f9-66f25136ff0f

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: GTEX
cancer_type_detailed: —
subtype: —
cancer_type: GTEX
sex: Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

SPERMATOGENESIS+0.301
KRAS_SIGNALING_DN+0.267
HEDGEHOG_SIGNALING+0.248
PANCREAS_BETA_CELLS+0.058
APICAL_SURFACE-0.019
WNT_BETA_CATENIN_SIGNALING-0.033
ESTROGEN_RESPONSE_EARLY-0.064
UV_RESPONSE_DN-0.074
MYOGENESIS-0.118
ESTROGEN_RESPONSE_LATE-0.137

Top 10 suppressed

MYC_TARGETS_V1-0.630
MTORC1_SIGNALING-0.505
ANDROGEN_RESPONSE-0.467
REACTIVE_OXYGEN_SPECIES_PATHWAY-0.458
PROTEIN_SECRETION-0.449
OXIDATIVE_PHOSPHORYLATION-0.447
ANGIOGENESIS-0.442
UNFOLDED_PROTEIN_RESPONSE-0.442
MYC_TARGETS_V2-0.441
DNA_REPAIR-0.430

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	SRR1334717 brain-umap@2	GTEX	—	0.966
2	BS_90B22NGP brain-umap@2	ATRT	—	0.963
3	SRR1432343 brain-umap@2	GTEX	—	0.961
4	SRR1466850 brain-umap@2	GTEX	—	0.957
5	SRR1406561 brain-umap@2	GTEX	—	0.954
6	SRR1336379 brain-umap@2	GTEX	—	0.954
7	BS_3P20Q2C3 brain-umap@2	low-grade glioma	—	0.952
8	SRR1323130 brain-umap@2	GTEX	—	0.950
9	SRR4195666 colon-landscapes@1	—	—	0.949
10	ERR4976613 breast-umap@18	—	D	0.949

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 4 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
SPERMATOGENESIS	0.301	Inavolisib	— uncovered
KRAS_SIGNALING_DN	0.267	Remibrutinib	— uncovered
HEDGEHOG_SIGNALING	0.248	Inavolisib	— uncovered
PANCREAS_BETA_CELLS	0.058	Cobimetinib	— uncovered