SRR1334717

GTEX

d3ba8679-1a2a-5623-bf38-dd04c58574f0

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: GTEX
cancer_type_detailed: —
subtype: —
cancer_type: GTEX
sex: Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

PANCREAS_BETA_CELLS+0.314
HEDGEHOG_SIGNALING+0.208
SPERMATOGENESIS+0.188
KRAS_SIGNALING_DN+0.173
PEROXISOME-0.078
APICAL_SURFACE-0.079
WNT_BETA_CATENIN_SIGNALING-0.117
BILE_ACID_METABOLISM-0.128
APICAL_JUNCTION-0.152
MYOGENESIS-0.160

Top 10 suppressed

MYC_TARGETS_V1-0.520
G2M_CHECKPOINT-0.480
IL6_JAK_STAT3_SIGNALING-0.471
E2F_TARGETS-0.461
TNFA_SIGNALING_VIA_NFKB-0.459
ANGIOGENESIS-0.448
MYC_TARGETS_V2-0.400
ANDROGEN_RESPONSE-0.398
TGF_BETA_SIGNALING-0.394
COMPLEMENT-0.392

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	SRR1321183 brain-umap@2	GTEX	—	0.968
2	SRR661179 brain-umap@2	GTEX	—	0.967
3	SRR1478032 brain-umap@2	GTEX	—	0.966
4	SRR1443713 brain-umap@2	GTEX	—	0.961
5	SRR4195666 colon-landscapes@1	—	—	0.951
6	MNG700 mng-umap@100	—	—	0.945
7	BS_3P20Q2C3 brain-umap@2	low-grade glioma	—	0.940
8	BS_90B22NGP brain-umap@2	ATRT	—	0.939
9	SRR1311182 brain-umap@2	GTEX	—	0.939
10	SRR1797231 lung-landscapes@6	—	cohortSC	0.937

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 4 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
PANCREAS_BETA_CELLS	0.314	Cobimetinib	— uncovered
HEDGEHOG_SIGNALING	0.208	Inavolisib	— uncovered
SPERMATOGENESIS	0.188	Inavolisib	— uncovered
KRAS_SIGNALING_DN	0.173	Remibrutinib	— uncovered