SRR8518441
— · D
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- D
- subtype
- D
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- HEDGEHOG_SIGNALING+0.190
- WNT_BETA_CATENIN_SIGNALING+0.150
- PANCREAS_BETA_CELLS+0.140
- MITOTIC_SPINDLE+0.130
- APICAL_SURFACE+0.120
- HYPOXIA+0.120
- CHOLESTEROL_HOMEOSTASIS+0.110
- E2F_TARGETS+0.070
- SPERMATOGENESIS+0.060
- PROTEIN_SECRETION+0.010
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.400
- MYC_TARGETS_V2-0.400
- INTERFERON_GAMMA_RESPONSE-0.370
- ALLOGRAFT_REJECTION-0.360
- TNFA_SIGNALING_VIA_NFKB-0.340
- INFLAMMATORY_RESPONSE-0.290
- COMPLEMENT-0.280
- IL6_JAK_STAT3_SIGNALING-0.280
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.270
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.270
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MDT-AP-3048 | Med | Medulloblastoma | 0.868 |
| 2 | C3N-00199 | — | cohortA1 | 0.813 |
| 3 | X3bde0089.a1cb.45b8.879b.4408eaa25707 | — | cohortMD1 | 0.806 |
| 4 | SRR4195697 | — | — | 0.800 |
| 5 | SRR1403875 | GTEX | — | 0.800 |
| 6 | SRR8392885 | — | cohortA3 | 0.799 |
| 7 | TCGA-GU-A42R-01A-11R-A23N-07 | — | — | 0.795 |
| 8 | MNG1289 | — | — | 0.793 |
| 9 | MNG214 | — | — | 0.790 |
| 10 | TCGA-BH-A1EV-01A-11R-A137-07 | — | C | 0.783 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| HEDGEHOG_SIGNALING | 0.190 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.150 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.140 | Cobimetinib | — uncovered |
| MITOTIC_SPINDLE | 0.130 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.120 | Temsirolimus | — uncovered |
| HYPOXIA | 0.120 | Idelalisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.110 | Remibrutinib | — uncovered |
| E2F_TARGETS | 0.070 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.060 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.010 | Remibrutinib | — uncovered |