SRR4195697
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- SPERMATOGENESIS+0.280
- WNT_BETA_CATENIN_SIGNALING+0.210
- PANCREAS_BETA_CELLS+0.160
- PROTEIN_SECRETION+0.110
- TGF_BETA_SIGNALING+0.100
- MTORC1_SIGNALING+0.020
- ANGIOGENESIS-0.020
- CHOLESTEROL_HOMEOSTASIS-0.020
- HEDGEHOG_SIGNALING-0.020
- UNFOLDED_PROTEIN_RESPONSE-0.020
Top 10 suppressed
- TNFA_SIGNALING_VIA_NFKB-0.480
- IL6_JAK_STAT3_SIGNALING-0.460
- INTERFERON_GAMMA_RESPONSE-0.410
- ALLOGRAFT_REJECTION-0.400
- INFLAMMATORY_RESPONSE-0.380
- APICAL_SURFACE-0.360
- XENOBIOTIC_METABOLISM-0.350
- OXIDATIVE_PHOSPHORYLATION-0.340
- ADIPOGENESIS-0.330
- COAGULATION-0.330
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR8613756 | — | E | 0.856 |
| 2 | C3N-00180 | — | cohortA3 | 0.847 |
| 3 | SRR8518450 | — | A | 0.843 |
| 4 | TCGA-A7-A13D-01B-04R-A277-07 | — | D | 0.836 |
| 5 | TCGA-CN-A49A-01A-11R-A24H-07 | — | — | 0.833 |
| 6 | TCGA-GU-A42R-01A-11R-A23N-07 | — | — | 0.830 |
| 7 | SRR8752376 | — | — | 0.821 |
| 8 | SRR12202470 | — | — | 0.821 |
| 9 | SRR2016964 | — | — | 0.821 |
| 10 | s0122214 | — | — | 0.819 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 6 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| SPERMATOGENESIS | 0.280 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.210 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.160 | Cobimetinib | — uncovered |
| PROTEIN_SECRETION | 0.110 | Remibrutinib | — uncovered |
| TGF_BETA_SIGNALING | 0.100 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.020 | Inavolisib | — uncovered |