MNG214
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MITOTIC_SPINDLE+0.286
- SPERMATOGENESIS+0.226
- HEME_METABOLISM+0.111
- KRAS_SIGNALING_DN+0.106
- PROTEIN_SECRETION+0.093
- G2M_CHECKPOINT+0.081
- ANDROGEN_RESPONSE+0.078
- CHOLESTEROL_HOMEOSTASIS+0.053
- HEDGEHOG_SIGNALING+0.035
- UV_RESPONSE_DN+0.027
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.486
- MYC_TARGETS_V2-0.435
- ANGIOGENESIS-0.427
- IL6_JAK_STAT3_SIGNALING-0.409
- INTERFERON_ALPHA_RESPONSE-0.401
- INTERFERON_GAMMA_RESPONSE-0.370
- ALLOGRAFT_REJECTION-0.360
- DNA_REPAIR-0.342
- OXIDATIVE_PHOSPHORYLATION-0.334
- UNFOLDED_PROTEIN_RESPONSE-0.333
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
6 twins match this tumor's tissue · 4 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | e356598b-7611-492a-98ed-ef2ec1b77b7a | — | — | 0.905 |
| 2 | SRR627451 | GTEX | — | 0.897 |
| 3 | SRR627429 | GTEX | — | 0.893 |
| 4 | MNG13 | — | — | 0.890 |
| 5 | 62454053-936d-4f19-8522-6219c47bdd1c | — | — | 0.875 |
| 6 | ed8896f8-24ef-43a4-ace6-ed9353bd11c2 | — | — | 0.874 |
| 7 | TCGA-BL-A0C8-01B-04R-A277-07 | — | — | 0.873 |
| 8 | SRR12696768 | — | — | 0.871 |
| 9 | SRR656745 | GTEX | — | 0.871 |
| 10 | SRR655555 | GTEX | — | 0.870 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MITOTIC_SPINDLE | 0.286 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.226 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.111 | Temsirolimus | — uncovered |
| KRAS_SIGNALING_DN | 0.106 | Remibrutinib | — uncovered |
| PROTEIN_SECRETION | 0.093 | Remibrutinib | — uncovered |
| G2M_CHECKPOINT | 0.081 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.078 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.053 | Remibrutinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.035 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.027 | Inavolisib | — uncovered |