SRR10900594
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.300
- PROTEIN_SECRETION+0.200
- ANDROGEN_RESPONSE+0.100
- APICAL_SURFACE+0.100
- HEME_METABOLISM+0.100
- BILE_ACID_METABOLISM+0.000
- FATTY_ACID_METABOLISM+0.000
- KRAS_SIGNALING_UP+0.000
- OXIDATIVE_PHOSPHORYLATION+0.000
- SPERMATOGENESIS+0.000
Top 10 suppressed
- E2F_TARGETS-0.500
- G2M_CHECKPOINT-0.500
- MYC_TARGETS_V2-0.400
- WNT_BETA_CATENIN_SIGNALING-0.400
- ALLOGRAFT_REJECTION-0.300
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.300
- MITOTIC_SPINDLE-0.300
- MTORC1_SIGNALING-0.300
- MYC_TARGETS_V1-0.300
- NOTCH_SIGNALING-0.300
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR975556 | — | — | 0.855 |
| 2 | SRR8518182 | — | C | 0.839 |
| 3 | AUR-AER8-TTP1-A-1-0-R-A741-41 | — | D | 0.837 |
| 4 | SRR33346948 | — | — | 0.837 |
| 5 | SRR8518163 | — | A | 0.829 |
| 6 | TCGA-CF-A47X-01A-31R-A23W-07 | — | — | 0.823 |
| 7 | MDT-AP-2993 | Med | Medulloblastoma | 0.819 |
| 8 | SRR975563 | — | — | 0.814 |
| 9 | SRR12475149 | — | — | 0.810 |
| 10 | SAMN03290937 | — | — | 0.809 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.300 | Cobimetinib | — uncovered |
| PROTEIN_SECRETION | 0.200 | Remibrutinib | — uncovered |
| ANDROGEN_RESPONSE | 0.100 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.100 | Temsirolimus | — uncovered |
| HEME_METABOLISM | 0.100 | Temsirolimus | — uncovered |