SRR12475149
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.300
- HEME_METABOLISM+0.140
- BILE_ACID_METABOLISM+0.050
- TGF_BETA_SIGNALING+0.050
- ESTROGEN_RESPONSE_EARLY+0.040
- P53_PATHWAY+0.030
- ANDROGEN_RESPONSE+0.010
- ESTROGEN_RESPONSE_LATE+0.010
- NOTCH_SIGNALING+0.000
- PANCREAS_BETA_CELLS-0.020
Top 10 suppressed
- E2F_TARGETS-0.570
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.560
- ANGIOGENESIS-0.500
- G2M_CHECKPOINT-0.490
- MTORC1_SIGNALING-0.460
- MYC_TARGETS_V2-0.460
- INTERFERON_GAMMA_RESPONSE-0.450
- IL6_JAK_STAT3_SIGNALING-0.430
- ALLOGRAFT_REJECTION-0.410
- INTERFERON_ALPHA_RESPONSE-0.410
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | eb67b977-b299-4bbc-b3f6-25d516473405 | — | — | 0.913 |
| 2 | SRR8942980 | — | — | 0.907 |
| 3 | SRR1516060 | — | — | 0.899 |
| 4 | TCGA-E7-A6MF-01A-12R-A32O-07 | — | — | 0.899 |
| 5 | SRR1516046 | — | — | 0.891 |
| 6 | TCGA-E2-A15G-01A-11R-A12D-07 | — | B | 0.890 |
| 7 | 7bcfb173-3654-42a1-8664-d0d074e4618c | — | — | 0.890 |
| 8 | 3ca8899d-3ed3-478b-a70c-919f68969d81 | — | — | 0.885 |
| 9 | C3N-03420 | — | cohortA1 | 0.885 |
| 10 | TCGA-MP-A5C7-01A-11R-A262-07 | — | cohortA2 | 0.884 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.300 | Remibrutinib | — uncovered |
| HEME_METABOLISM | 0.140 | Temsirolimus | — uncovered |
| BILE_ACID_METABOLISM | 0.050 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.050 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.040 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.030 | Idelalisib | — uncovered |
| ANDROGEN_RESPONSE | 0.010 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.010 | Idelalisib | — uncovered |