MNG851
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- NOTCH_SIGNALING+0.202
- KRAS_SIGNALING_DN+0.110
- APICAL_JUNCTION+0.091
- WNT_BETA_CATENIN_SIGNALING+0.087
- PEROXISOME+0.024
- UV_RESPONSE_UP+0.016
- MYOGENESIS+0.012
- SPERMATOGENESIS-0.040
- HEME_METABOLISM-0.061
- HEDGEHOG_SIGNALING-0.070
Top 10 suppressed
- PROTEIN_SECRETION-0.506
- ANGIOGENESIS-0.465
- KRAS_SIGNALING_UP-0.440
- INTERFERON_GAMMA_RESPONSE-0.439
- INTERFERON_ALPHA_RESPONSE-0.434
- TNFA_SIGNALING_VIA_NFKB-0.429
- MYC_TARGETS_V1-0.425
- MTORC1_SIGNALING-0.417
- ALLOGRAFT_REJECTION-0.416
- INFLAMMATORY_RESPONSE-0.409
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
4 twins match this tumor's tissue · 6 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MDT-AP-1120 | Med | Medulloblastoma | 0.934 |
| 2 | SRR1350107 | GTEX | — | 0.920 |
| 3 | SRR1404168 | GTEX | — | 0.918 |
| 4 | SRR1797247 | — | cohortSC | 0.917 |
| 5 | SRR1388504 | GTEX | — | 0.916 |
| 6 | R87 | — | — | 0.914 |
| 7 | ea635e80-1225-4f52-a6cf-8f4c20201240 | — | — | 0.909 |
| 8 | SRR1364800 | GTEX | — | 0.905 |
| 9 | SRR1489054 | GTEX | — | 0.904 |
| 10 | MBCProject_0719_T1_RNA | — | A | 0.904 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| NOTCH_SIGNALING | 0.202 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.110 | Remibrutinib | — uncovered |
| APICAL_JUNCTION | 0.091 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.087 | Inavolisib | — uncovered |
| PEROXISOME | 0.024 | Idelalisib | — uncovered |
| UV_RESPONSE_UP | 0.016 | Idelalisib | — uncovered |
| MYOGENESIS | 0.012 | Inavolisib | — uncovered |