SRR6013507
— · cohortMD2
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortMD2
- subtype
- cohortMD2
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- UNFOLDED_PROTEIN_RESPONSE+0.240
- ALLOGRAFT_REJECTION+0.200
- PANCREAS_BETA_CELLS+0.110
- PROTEIN_SECRETION+0.110
- SPERMATOGENESIS+0.070
- UV_RESPONSE_DN+0.060
- INTERFERON_GAMMA_RESPONSE+0.020
- KRAS_SIGNALING_UP-0.020
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.060
- HEME_METABOLISM-0.070
Top 10 suppressed
- E2F_TARGETS-0.490
- ESTROGEN_RESPONSE_LATE-0.430
- APICAL_SURFACE-0.410
- FATTY_ACID_METABOLISM-0.400
- OXIDATIVE_PHOSPHORYLATION-0.400
- P53_PATHWAY-0.400
- CHOLESTEROL_HOMEOSTASIS-0.380
- G2M_CHECKPOINT-0.380
- MITOTIC_SPINDLE-0.370
- ESTROGEN_RESPONSE_EARLY-0.360
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR12202440 | — | — | 0.848 |
| 2 | R2 | — | — | 0.841 |
| 3 | AUR-AD9G-TTP1-B-4-0-R-A584-39 | — | D | 0.831 |
| 4 | TCGA-AC-A3OD-01A-11R-A21T-07 | — | D | 0.828 |
| 5 | d1447a31-64bb-4e70-ae50-eeff7a605f38 | — | — | 0.821 |
| 6 | b8135e73-31c3-49af-b4da-a7ed5f28d68a | — | — | 0.820 |
| 7 | SRR8943010 | — | — | 0.815 |
| 8 | SRR8942981 | — | — | 0.814 |
| 9 | SAMN03290914 | — | — | 0.811 |
| 10 | AUR-AERW-TTP1-B-1-0-R-A741-41 | — | D | 0.810 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| UNFOLDED_PROTEIN_RESPONSE | 0.240 | Idelalisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.200 | Idelalisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.110 | Cobimetinib | — uncovered |
| PROTEIN_SECRETION | 0.110 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.070 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.060 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.020 | Idelalisib | — uncovered |