Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

MNG1078

28e17282-c5fe-5b39-bad8-cfd04ae7cb35

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • KRAS_SIGNALING_DN+0.268
  • E2F_TARGETS+0.189
  • SPERMATOGENESIS+0.157
  • G2M_CHECKPOINT+0.118
  • OXIDATIVE_PHOSPHORYLATION+0.102
  • MYOGENESIS+0.069
  • PANCREAS_BETA_CELLS+0.054
  • KRAS_SIGNALING_UP+0.051
  • HEDGEHOG_SIGNALING+0.023
  • MYC_TARGETS_V2+0.016

Top 10 suppressed

  • INTERFERON_ALPHA_RESPONSE-0.570
  • PROTEIN_SECRETION-0.531
  • MYC_TARGETS_V1-0.425
  • INTERFERON_GAMMA_RESPONSE-0.418
  • ANDROGEN_RESPONSE-0.411
  • UV_RESPONSE_DN-0.389
  • APOPTOSIS-0.383
  • FATTY_ACID_METABOLISM-0.358
  • PEROXISOME-0.355
  • UNFOLDED_PROTEIN_RESPONSE-0.339

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MNG159
mng-umap@100
0.871
2MNG542
mng-umap@100
0.865
3SRR6013541
lung-landscapes@6
cohortSQ10.835
4MNG1093
mng-umap@100
0.831
5SRR650150
bladder-landscape@3
0.828
6MNG84
mng-umap@100
0.824
7MNG959
mng-umap@100
0.818
8MNG604
mng-umap@100
0.816
9MNG459
mng-umap@100
0.813
10MNG1257
mng-umap@100
0.812

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 10 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
KRAS_SIGNALING_DN0.268Remibrutinib— uncovered
E2F_TARGETS0.189Inavolisib— uncovered
SPERMATOGENESIS0.157Inavolisib— uncovered
G2M_CHECKPOINT0.118Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.102Remibrutinib— uncovered
MYOGENESIS0.069Inavolisib— uncovered
PANCREAS_BETA_CELLS0.054Cobimetinib— uncovered
KRAS_SIGNALING_UP0.051Inavolisib— uncovered
HEDGEHOG_SIGNALING0.023Inavolisib— uncovered
MYC_TARGETS_V20.016Idelalisib— uncovered