MNG959
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.229
- PANCREAS_BETA_CELLS+0.190
- SPERMATOGENESIS+0.116
- ANGIOGENESIS+0.077
- ALLOGRAFT_REJECTION-0.017
- INFLAMMATORY_RESPONSE-0.019
- APICAL_SURFACE-0.038
- E2F_TARGETS-0.074
- WNT_BETA_CATENIN_SIGNALING-0.119
- COMPLEMENT-0.123
Top 10 suppressed
- TGF_BETA_SIGNALING-0.566
- PROTEIN_SECRETION-0.494
- UNFOLDED_PROTEIN_RESPONSE-0.491
- CHOLESTEROL_HOMEOSTASIS-0.489
- ANDROGEN_RESPONSE-0.479
- MYC_TARGETS_V1-0.464
- INTERFERON_ALPHA_RESPONSE-0.434
- HEME_METABOLISM-0.430
- UV_RESPONSE_DN-0.404
- MTORC1_SIGNALING-0.398
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1452056 | GTEX | — | 0.940 |
| 2 | MNG555 | — | — | 0.932 |
| 3 | MNG598 | — | — | 0.930 |
| 4 | SRR26320081 | — | — | 0.925 |
| 5 | SRR26320083 | — | — | 0.918 |
| 6 | MNG1003 | — | — | 0.918 |
| 7 | SRR13311179 | — | — | 0.917 |
| 8 | 08e3d239-3d8a-4eee-9e08-ac2bcb3f2619 | — | — | 0.916 |
| 9 | msclc569389_S35.txt | — | cohortMD1 | 0.916 |
| 10 | SRR4195666 | — | — | 0.914 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 4 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.229 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.190 | Cobimetinib | — uncovered |
| SPERMATOGENESIS | 0.116 | Inavolisib | — uncovered |
| ANGIOGENESIS | 0.077 | Remibrutinib | — uncovered |