Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-G2-AA3B-01A-11R-A39I-07

29db31a9-5525-58ca-b299-d476404442b1

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
65.96583443
os_event
false
sex
Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • FATTY_ACID_METABOLISM+0.370
  • BILE_ACID_METABOLISM+0.330
  • INTERFERON_ALPHA_RESPONSE+0.270
  • KRAS_SIGNALING_DN+0.200
  • PANCREAS_BETA_CELLS+0.170
  • E2F_TARGETS+0.160
  • OXIDATIVE_PHOSPHORYLATION+0.150
  • XENOBIOTIC_METABOLISM+0.140
  • ALLOGRAFT_REJECTION+0.080
  • APICAL_SURFACE+0.080

Top 10 suppressed

  • TGF_BETA_SIGNALING-0.530
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.500
  • UV_RESPONSE_DN-0.440
  • MITOTIC_SPINDLE-0.390
  • WNT_BETA_CATENIN_SIGNALING-0.390
  • APICAL_JUNCTION-0.350
  • TNFA_SIGNALING_VIA_NFKB-0.350
  • P53_PATHWAY-0.330
  • APOPTOSIS-0.300
  • PI3K_AKT_MTOR_SIGNALING-0.300

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1R11
bladder-landscape@3
0.822
2TCGA-GD-A6C6-01A-21R-A31N-07
bladder-landscape@3
0.821
3TCGA-E7-A4IJ-01A-31R-A26T-07
bladder-landscape@3
0.814
4TCGA-78-7147-01A-11R-2039-07
lung-landscapes@6
cohortA10.812
5TCGA-IQ-A61I-01A-11R-A30B-07
head-neck@1
0.802
6SRR4195696
colon-landscapes@1
0.777
7TCGA-XF-A8HC-01A-11R-A36F-07
bladder-landscape@3
0.773
8SRR33346946
bladder-landscape@3
0.773
9SRR25617833
breast-umap@18
B0.761
10SRR23303738
bladder-landscape@3
0.760

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 16 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
FATTY_ACID_METABOLISM0.370Inavolisib— uncovered
BILE_ACID_METABOLISM0.330Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.270Inavolisib— uncovered
KRAS_SIGNALING_DN0.200Remibrutinib— uncovered
PANCREAS_BETA_CELLS0.170Cobimetinib— uncovered
E2F_TARGETS0.160Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.150Remibrutinib— uncovered
XENOBIOTIC_METABOLISM0.140Inavolisib— uncovered
ALLOGRAFT_REJECTION0.080Idelalisib— uncovered
APICAL_SURFACE0.080Temsirolimus— uncovered
SPERMATOGENESIS0.040Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.030Remibrutinib— uncovered
PEROXISOME0.030Idelalisib— uncovered
ADIPOGENESIS0.020Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.020Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.020Idelalisib— uncovered