TCGA-E7-A4IJ-01A-31R-A26T-07
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- overall_survival_months
- 22.14191853
- os_event
- true
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.370
- PEROXISOME+0.210
- INTERFERON_GAMMA_RESPONSE+0.190
- PANCREAS_BETA_CELLS+0.190
- SPERMATOGENESIS+0.160
- FATTY_ACID_METABOLISM+0.130
- BILE_ACID_METABOLISM+0.060
- ALLOGRAFT_REJECTION+0.050
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.040
- XENOBIOTIC_METABOLISM+0.040
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.480
- ANGIOGENESIS-0.410
- TGF_BETA_SIGNALING-0.370
- P53_PATHWAY-0.360
- MYC_TARGETS_V1-0.350
- UV_RESPONSE_DN-0.340
- COAGULATION-0.310
- HYPOXIA-0.310
- ANDROGEN_RESPONSE-0.260
- TNFA_SIGNALING_VIA_NFKB-0.260
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-DK-A6B6-01A-11R-A30C-07 | — | — | 0.847 |
| 2 | SRR25617833 | — | B | 0.831 |
| 3 | SRR33346946 | — | — | 0.827 |
| 4 | TCGA-G2-AA3B-01A-11R-A39I-07 | — | — | 0.814 |
| 5 | R11 | — | — | 0.796 |
| 6 | TCGA-78-7147-01A-11R-2039-07 | — | cohortA1 | 0.790 |
| 7 | TCGA-CV-A461-01A-41R-A266-07 | — | — | 0.788 |
| 8 | SAMN03290914 | — | — | 0.787 |
| 9 | TCGA-EW-A1J6-01A-11R-A13Q-07 | — | B | 0.783 |
| 10 | TCGA-49-AAQV-01A-11R-A39D-07 | — | cohortA1 | 0.782 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.370 | Inavolisib | — uncovered |
| PEROXISOME | 0.210 | Idelalisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.190 | Idelalisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.190 | Cobimetinib | — uncovered |
| SPERMATOGENESIS | 0.160 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.130 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.060 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.050 | Idelalisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.040 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.040 | Inavolisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.010 | Inavolisib | — uncovered |