TCGA-78-7147-01A-11R-2039-07
— · cohortA1
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortA1
- subtype
- cohortA1
- age_years
- 67
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.380
- PEROXISOME+0.210
- BILE_ACID_METABOLISM+0.200
- DNA_REPAIR+0.140
- INTERFERON_GAMMA_RESPONSE+0.100
- GLYCOLYSIS+0.080
- FATTY_ACID_METABOLISM+0.040
- OXIDATIVE_PHOSPHORYLATION+0.040
- ADIPOGENESIS+0.020
- E2F_TARGETS+0.020
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.520
- TNFA_SIGNALING_VIA_NFKB-0.470
- WNT_BETA_CATENIN_SIGNALING-0.400
- MYC_TARGETS_V2-0.390
- TGF_BETA_SIGNALING-0.360
- HYPOXIA-0.340
- ANGIOGENESIS-0.330
- HEDGEHOG_SIGNALING-0.330
- IL6_JAK_STAT3_SIGNALING-0.330
- INFLAMMATORY_RESPONSE-0.330
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-G2-AA3B-01A-11R-A39I-07 | — | — | 0.812 |
| 2 | AUR-AD9H-TTM2-A-1-1-R-A542-39 | — | B | 0.808 |
| 3 | 42371f73-e570-4ec7-ac5d-b4718183c1e8 | — | — | 0.803 |
| 4 | TCGA-QK-A8Z8-01A-11R-A39I-07 | — | — | 0.793 |
| 5 | TCGA-E7-A4IJ-01A-31R-A26T-07 | — | — | 0.790 |
| 6 | MBCProject_0076_T1_RNA | — | B | 0.781 |
| 7 | 20040020.LumA | — | B | 0.779 |
| 8 | SRR2755094 | — | — | 0.776 |
| 9 | AUR-AEPZ-TTM1-A-1-1-R-A742-41 | — | B | 0.771 |
| 10 | R311 | — | — | 0.771 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.380 | Inavolisib | — uncovered |
| PEROXISOME | 0.210 | Idelalisib | — uncovered |
| BILE_ACID_METABOLISM | 0.200 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.140 | Idelalisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.100 | Idelalisib | — uncovered |
| GLYCOLYSIS | 0.080 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.040 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.040 | Remibrutinib | — uncovered |
| ADIPOGENESIS | 0.020 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.020 | Inavolisib | — uncovered |