Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

E92DD0CC-DD0F-469D-8357-228A4A67DBD6

31d42250-e7b7-591d-8140-3d4ccf33bc63

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
14.71747700394218
age_years
36
sex
Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • MYC_TARGETS_V1+0.650
  • E2F_TARGETS+0.642
  • DNA_REPAIR+0.548
  • G2M_CHECKPOINT+0.548
  • OXIDATIVE_PHOSPHORYLATION+0.543
  • INTERFERON_ALPHA_RESPONSE+0.525
  • MYC_TARGETS_V2+0.513
  • INTERFERON_GAMMA_RESPONSE+0.492
  • ALLOGRAFT_REJECTION+0.473
  • MTORC1_SIGNALING+0.416

Top 10 suppressed

  • KRAS_SIGNALING_DN-0.364
  • HEDGEHOG_SIGNALING-0.302
  • MYOGENESIS-0.282
  • BILE_ACID_METABOLISM-0.266
  • ESTROGEN_RESPONSE_EARLY-0.259
  • HEME_METABOLISM-0.228
  • UV_RESPONSE_DN-0.209
  • APICAL_SURFACE-0.163
  • APICAL_JUNCTION-0.104
  • MITOTIC_SPINDLE-0.040

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1A43D720D-0CA3-48CF-ADC7-5AC72BD5EEA9
brain-umap@2
0.965
2F2EB65DD-59F7-4C1F-8D92-0DCF439FF41A
brain-umap@2
0.964
3E7BE221B-273D-4C04-BE79-366E6455EFBC
brain-umap@2
0.959
4FCD3124F-0F41-448E-B2B9-D9934D4EC1A7
brain-umap@2
0.958
5A2170829-B80C-49F2-8FB6-39B8ACFB27CB
brain-umap@2
0.955
6AB5294B5-4A59-493A-9016-C2778735745F
brain-umap@2
0.954
7AF548E30-7121-4F9F-A2CD-F1A540E9C4EE
brain-umap@2
0.950
8BB96C5BA-CA50-40B4-B22A-3FCFE46AB11C
brain-umap@2
0.949
9B99430AD-6309-4B90-A0AA-A5B2FA746246
brain-umap@2
0.944
106410821A-1C6A-4F64-939F-196313B8F1E5
brain-umap@2
0.942

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 38 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V10.650Inavolisib— uncovered
E2F_TARGETS0.642Inavolisib— uncovered
DNA_REPAIR0.548Idelalisib— uncovered
G2M_CHECKPOINT0.548Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.543Remibrutinib— uncovered
INTERFERON_ALPHA_RESPONSE0.525Inavolisib— uncovered
MYC_TARGETS_V20.513Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.492Idelalisib— uncovered
ALLOGRAFT_REJECTION0.473Idelalisib— uncovered
MTORC1_SIGNALING0.416Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.403Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.371Inavolisib— uncovered
APOPTOSIS0.362Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.349Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.347Inavolisib— uncovered
ANGIOGENESIS0.332Remibrutinib— uncovered
GLYCOLYSIS0.325Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.308Idelalisib— uncovered
COAGULATION0.299Binimetinib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.297Inavolisib— uncovered