SRR1322270
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- DNA_REPAIR+0.194
- MYC_TARGETS_V2+0.193
- UNFOLDED_PROTEIN_RESPONSE+0.127
- PROTEIN_SECRETION+0.120
- MYC_TARGETS_V1+0.101
- MITOTIC_SPINDLE+0.088
- PI3K_AKT_MTOR_SIGNALING+0.087
- OXIDATIVE_PHOSPHORYLATION+0.054
- E2F_TARGETS+0.018
- PEROXISOME+0.002
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.637
- ANGIOGENESIS-0.568
- INTERFERON_GAMMA_RESPONSE-0.546
- TNFA_SIGNALING_VIA_NFKB-0.542
- INFLAMMATORY_RESPONSE-0.533
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.522
- COAGULATION-0.490
- TGF_BETA_SIGNALING-0.476
- IL6_JAK_STAT3_SIGNALING-0.475
- ALLOGRAFT_REJECTION-0.473
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1321244 | GTEX | — | 0.991 |
| 2 | SRR1472621 | GTEX | — | 0.989 |
| 3 | SRR1421140 | GTEX | — | 0.988 |
| 4 | SRR1406917 | GTEX | — | 0.988 |
| 5 | SRR1351325 | GTEX | — | 0.986 |
| 6 | SRR1456841 | GTEX | — | 0.986 |
| 7 | SRR1317323 | GTEX | — | 0.985 |
| 8 | SRR1490382 | GTEX | — | 0.985 |
| 9 | SRR1410934 | GTEX | — | 0.984 |
| 10 | SRR1458422 | GTEX | — | 0.984 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| DNA_REPAIR | 0.194 | Idelalisib | — uncovered |
| MYC_TARGETS_V2 | 0.193 | Idelalisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.127 | Idelalisib | — uncovered |
| PROTEIN_SECRETION | 0.120 | Remibrutinib | — uncovered |
| MYC_TARGETS_V1 | 0.101 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.088 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.087 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.054 | Remibrutinib | — uncovered |
| E2F_TARGETS | 0.018 | Inavolisib | — uncovered |
| PEROXISOME | 0.002 | Idelalisib | — uncovered |