SRR12202414
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.280
- INTERFERON_ALPHA_RESPONSE+0.150
- SPERMATOGENESIS+0.150
- PANCREAS_BETA_CELLS+0.100
- KRAS_SIGNALING_DN+0.070
- OXIDATIVE_PHOSPHORYLATION+0.070
- INTERFERON_GAMMA_RESPONSE+0.060
- ALLOGRAFT_REJECTION-0.010
- IL6_JAK_STAT3_SIGNALING-0.010
- UNFOLDED_PROTEIN_RESPONSE-0.010
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.460
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.430
- P53_PATHWAY-0.410
- ESTROGEN_RESPONSE_EARLY-0.370
- ANGIOGENESIS-0.350
- CHOLESTEROL_HOMEOSTASIS-0.350
- HYPOXIA-0.340
- ESTROGEN_RESPONSE_LATE-0.330
- APICAL_SURFACE-0.320
- GLYCOLYSIS-0.320
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SAMN03290914 | — | — | 0.883 |
| 2 | SRR25617833 | — | B | 0.862 |
| 3 | SRR25617910 | — | B | 0.855 |
| 4 | SRR33346946 | — | — | 0.843 |
| 5 | 9cde93c5-569a-482a-901b-2bbc21aadfa2 | — | — | 0.833 |
| 6 | TCGA-ZF-A9R5-01A-12R-A42T-07 | — | — | 0.817 |
| 7 | SRR6013507 | — | cohortMD2 | 0.809 |
| 8 | SRR934898 | — | — | 0.807 |
| 9 | SRR1313096 | — | B | 0.803 |
| 10 | R2 | — | — | 0.803 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.280 | Remibrutinib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.150 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.150 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.100 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.070 | Remibrutinib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.070 | Remibrutinib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.060 | Idelalisib | — uncovered |