AUR-AF9A-TTP1-A-1-0-R-A741-41
— · D
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- D
- subtype
- D
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.430
- INTERFERON_GAMMA_RESPONSE+0.310
- WNT_BETA_CATENIN_SIGNALING+0.150
- SPERMATOGENESIS+0.080
- KRAS_SIGNALING_DN+0.010
- G2M_CHECKPOINT-0.010
- E2F_TARGETS-0.050
- MITOTIC_SPINDLE-0.050
- UV_RESPONSE_DN-0.100
- HEME_METABOLISM-0.110
Top 10 suppressed
- ANGIOGENESIS-0.580
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.520
- COAGULATION-0.510
- MYC_TARGETS_V1-0.480
- MYC_TARGETS_V2-0.480
- MTORC1_SIGNALING-0.460
- ESTROGEN_RESPONSE_EARLY-0.430
- UNFOLDED_PROTEIN_RESPONSE-0.420
- CHOLESTEROL_HOMEOSTASIS-0.410
- HYPOXIA-0.400
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR4195665 | — | — | 0.890 |
| 2 | 20040121.LumB | — | D | 0.886 |
| 3 | SRR650134 | — | — | 0.866 |
| 4 | TCGA-60-2721-01A-01R-0851-07 | — | cohortSQ1 | 0.860 |
| 5 | SAMN03290914 | — | — | 0.858 |
| 6 | ERR2208899 | — | — | 0.854 |
| 7 | SRR23303775 | — | — | 0.853 |
| 8 | TCGA-P3-A5QE-01A-11R-A28V-07 | — | — | 0.853 |
| 9 | AUR-AFSP-TTP1-A-8-0-R-A741-41 | — | D | 0.852 |
| 10 | MBCProject_4647_T0_RNA | — | B | 0.840 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.430 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.310 | Idelalisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.150 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.080 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.010 | Remibrutinib | — uncovered |