0918cbd5-edd0-41c8-8b67-677f35ad4611
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MITOTIC_SPINDLE+0.500
- TGF_BETA_SIGNALING+0.500
- E2F_TARGETS+0.400
- G2M_CHECKPOINT+0.400
- UV_RESPONSE_DN+0.400
- NOTCH_SIGNALING+0.300
- WNT_BETA_CATENIN_SIGNALING+0.300
- ANGIOGENESIS+0.200
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.200
- APICAL_JUNCTION+0.100
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.600
- INTERFERON_GAMMA_RESPONSE-0.500
- OXIDATIVE_PHOSPHORYLATION-0.500
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.500
- ALLOGRAFT_REJECTION-0.400
- CHOLESTEROL_HOMEOSTASIS-0.400
- IL6_JAK_STAT3_SIGNALING-0.400
- INFLAMMATORY_RESPONSE-0.400
- MYC_TARGETS_V2-0.400
- XENOBIOTIC_METABOLISM-0.400
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR5088885 | — | — | 0.909 |
| 2 | b0be4742-ccb7-48e2-b756-0c384321114e | — | — | 0.898 |
| 3 | s0122214 | — | — | 0.891 |
| 4 | SRR5088886 | — | — | 0.878 |
| 5 | 20100144.Her2HRpos | — | D | 0.870 |
| 6 | ERR2208889 | — | — | 0.863 |
| 7 | SRR2932838 | — | — | 0.858 |
| 8 | SRR8613768 | — | E | 0.850 |
| 9 | TCGA-AC-A2QH-01B-04R-A22O-07 | — | D | 0.848 |
| 10 | TCGA-CR-7370-01A-11R-2132-07 | — | — | 0.844 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MITOTIC_SPINDLE | 0.500 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.500 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.400 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.400 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.400 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.300 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.300 | Inavolisib | — uncovered |
| ANGIOGENESIS | 0.200 | Remibrutinib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.200 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.100 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.100 | Inavolisib | — uncovered |
| MYOGENESIS | 0.100 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.100 | Inavolisib | — uncovered |