SRR1472621
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- DNA_REPAIR+0.173
- MYC_TARGETS_V2+0.128
- UNFOLDED_PROTEIN_RESPONSE+0.071
- MITOTIC_SPINDLE+0.064
- MYC_TARGETS_V1+0.058
- PI3K_AKT_MTOR_SIGNALING+0.049
- KRAS_SIGNALING_DN+0.037
- PROTEIN_SECRETION+0.007
- OXIDATIVE_PHOSPHORYLATION-0.025
- PEROXISOME-0.032
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.607
- INTERFERON_GAMMA_RESPONSE-0.540
- TNFA_SIGNALING_VIA_NFKB-0.539
- INFLAMMATORY_RESPONSE-0.538
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.528
- IL6_JAK_STAT3_SIGNALING-0.470
- KRAS_SIGNALING_UP-0.466
- APOPTOSIS-0.457
- NOTCH_SIGNALING-0.451
- ANGIOGENESIS-0.450
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1490382 | GTEX | — | 0.990 |
| 2 | SRR1322270 | GTEX | — | 0.989 |
| 3 | SRR1456841 | GTEX | — | 0.987 |
| 4 | SRR1421140 | GTEX | — | 0.987 |
| 5 | SRR1429307 | GTEX | — | 0.983 |
| 6 | SRR1361714 | GTEX | — | 0.983 |
| 7 | SRR1321244 | GTEX | — | 0.982 |
| 8 | SRR1335029 | GTEX | — | 0.981 |
| 9 | SRR1355061 | GTEX | — | 0.980 |
| 10 | SRR1319672 | GTEX | — | 0.980 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| DNA_REPAIR | 0.173 | Idelalisib | — uncovered |
| MYC_TARGETS_V2 | 0.128 | Idelalisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.071 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.064 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.058 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.049 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.037 | Remibrutinib | — uncovered |
| PROTEIN_SECRETION | 0.007 | Remibrutinib | — uncovered |