SRR1433750
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.555
- SPERMATOGENESIS+0.325
- KRAS_SIGNALING_DN+0.263
- BILE_ACID_METABOLISM+0.245
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.245
- OXIDATIVE_PHOSPHORYLATION+0.241
- FATTY_ACID_METABOLISM+0.174
- ESTROGEN_RESPONSE_LATE+0.132
- ADIPOGENESIS+0.084
- PEROXISOME+0.081
Top 10 suppressed
- MITOTIC_SPINDLE-0.485
- MYC_TARGETS_V2-0.481
- TGF_BETA_SIGNALING-0.392
- TNFA_SIGNALING_VIA_NFKB-0.372
- IL6_JAK_STAT3_SIGNALING-0.337
- PI3K_AKT_MTOR_SIGNALING-0.320
- UNFOLDED_PROTEIN_RESPONSE-0.315
- WNT_BETA_CATENIN_SIGNALING-0.304
- APICAL_JUNCTION-0.292
- G2M_CHECKPOINT-0.289
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1435293 | GTEX | — | 0.885 |
| 2 | SRR1321046 | GTEX | — | 0.882 |
| 3 | SRR1323764 | GTEX | — | 0.848 |
| 4 | SRR1318426 | GTEX | — | 0.846 |
| 5 | SRR1415095 | GTEX | — | 0.834 |
| 6 | SRR1498640 | GTEX | — | 0.833 |
| 7 | SRR1474466 | GTEX | — | 0.830 |
| 8 | MNG543 | — | — | 0.828 |
| 9 | SRR818418 | GTEX | — | 0.823 |
| 10 | SRR1437306 | GTEX | — | 0.822 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.555 | Cobimetinib | — uncovered |
| SPERMATOGENESIS | 0.325 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.263 | Remibrutinib | — uncovered |
| BILE_ACID_METABOLISM | 0.245 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.245 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.241 | Remibrutinib | — uncovered |
| FATTY_ACID_METABOLISM | 0.174 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.132 | Idelalisib | — uncovered |
| ADIPOGENESIS | 0.084 | Inavolisib | — uncovered |
| PEROXISOME | 0.081 | Idelalisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.078 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.043 | Remibrutinib | — uncovered |
| KRAS_SIGNALING_UP | 0.023 | Inavolisib | — uncovered |