52ed30fb-f32a-4b5b-9ab6-e67438e9da8f
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.500
- INTERFERON_GAMMA_RESPONSE+0.300
- PANCREAS_BETA_CELLS+0.300
- IL6_JAK_STAT3_SIGNALING+0.200
- MYC_TARGETS_V2+0.200
- WNT_BETA_CATENIN_SIGNALING+0.200
- ANGIOGENESIS+0.100
- ALLOGRAFT_REJECTION+0.000
- COAGULATION+0.000
- IL2_STAT5_SIGNALING+0.000
Top 10 suppressed
- APICAL_JUNCTION-0.300
- E2F_TARGETS-0.300
- G2M_CHECKPOINT-0.300
- MTORC1_SIGNALING-0.300
- OXIDATIVE_PHOSPHORYLATION-0.300
- TGF_BETA_SIGNALING-0.300
- APICAL_SURFACE-0.200
- CHOLESTEROL_HOMEOSTASIS-0.200
- COMPLEMENT-0.200
- DNA_REPAIR-0.200
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG882 | — | — | 0.708 |
| 2 | SRR8518305 | — | D | 0.707 |
| 3 | ERR4976617 | — | D | 0.705 |
| 4 | eb84c7b1-da0d-48cb-ba8b-0c1f2b3df4cd | — | — | 0.704 |
| 5 | SRR13311156 | — | — | 0.701 |
| 6 | TCGA-62-A472-01A-11R-A24H-07 | — | cohortA1 | 0.699 |
| 7 | SRR12202481 | — | — | 0.696 |
| 8 | SAMN03290916 | — | — | 0.692 |
| 9 | SAMN03290914 | — | — | 0.691 |
| 10 | TCGA-MN-A4N5-01A-11R-A24X-07 | — | cohortA1 | 0.689 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.500 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.300 | Idelalisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.300 | Cobimetinib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.200 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.200 | Idelalisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.200 | Inavolisib | — uncovered |
| ANGIOGENESIS | 0.100 | Remibrutinib | — uncovered |