SRR15030890
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- WNT_BETA_CATENIN_SIGNALING+0.210
- MITOTIC_SPINDLE+0.170
- MYC_TARGETS_V2+0.130
- P53_PATHWAY+0.100
- GLYCOLYSIS+0.060
- NOTCH_SIGNALING+0.060
- UNFOLDED_PROTEIN_RESPONSE+0.060
- APICAL_SURFACE+0.040
- UV_RESPONSE_DN+0.030
- PI3K_AKT_MTOR_SIGNALING+0.020
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.430
- ALLOGRAFT_REJECTION-0.400
- IL6_JAK_STAT3_SIGNALING-0.400
- INFLAMMATORY_RESPONSE-0.370
- COAGULATION-0.340
- OXIDATIVE_PHOSPHORYLATION-0.340
- ANGIOGENESIS-0.300
- COMPLEMENT-0.300
- TNFA_SIGNALING_VIA_NFKB-0.300
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.290
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR650167 | — | — | 0.887 |
| 2 | SRR604146 | GTEX | — | 0.869 |
| 3 | 302722c6-102e-4b1b-845e-78920380e337 | — | — | 0.868 |
| 4 | MDT-AP-1138 | Med | Medulloblastoma | 0.857 |
| 5 | s0102877 | — | — | 0.849 |
| 6 | SRR650200 | — | — | 0.848 |
| 7 | SJEPD031175_D1.RNA-Seq | EPN | Posterior Fossa EPN | 0.847 |
| 8 | ERR2208948 | — | — | 0.846 |
| 9 | SRR8613756 | — | E | 0.845 |
| 10 | 50d87a6b-8e96-4964-9f23-53cc48c7d9ff | — | — | 0.844 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| WNT_BETA_CATENIN_SIGNALING | 0.210 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.170 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.130 | Idelalisib | — uncovered |
| P53_PATHWAY | 0.100 | Idelalisib | — uncovered |
| GLYCOLYSIS | 0.060 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.060 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.060 | Idelalisib | — uncovered |
| APICAL_SURFACE | 0.040 | Temsirolimus | — uncovered |
| UV_RESPONSE_DN | 0.030 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.020 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.010 | Inavolisib | — uncovered |