SRR8613756
— · E
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- E
- subtype
- E
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- HEDGEHOG_SIGNALING+0.270
- MITOTIC_SPINDLE+0.150
- PROTEIN_SECRETION+0.130
- TGF_BETA_SIGNALING+0.110
- SPERMATOGENESIS+0.070
- MYC_TARGETS_V2+0.050
- DNA_REPAIR+0.030
- WNT_BETA_CATENIN_SIGNALING+0.020
- UV_RESPONSE_DN-0.010
- UNFOLDED_PROTEIN_RESPONSE-0.060
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.730
- INTERFERON_GAMMA_RESPONSE-0.670
- ALLOGRAFT_REJECTION-0.640
- INFLAMMATORY_RESPONSE-0.610
- IL6_JAK_STAT3_SIGNALING-0.560
- COMPLEMENT-0.550
- TNFA_SIGNALING_VIA_NFKB-0.540
- IL2_STAT5_SIGNALING-0.480
- MTORC1_SIGNALING-0.470
- COAGULATION-0.460
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
4 twins match this tumor's tissue · 6 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR650167 | — | — | 0.909 |
| 2 | SRR8518450 | — | A | 0.908 |
| 3 | TCGA-OR-A5L8-01 | Adrenocortical Carcinoma | Adrenocortical Carcinoma, Usual Type | 0.902 |
| 4 | MDT-AP-0189 | Med | Medulloblastoma | 0.896 |
| 5 | s0102877 | — | — | 0.896 |
| 6 | s_150324_3b | EPN | Posterior Fossa EPN | 0.887 |
| 7 | SRR1324452 | GTEX | — | 0.885 |
| 8 | SRR1441224 | GTEX | — | 0.881 |
| 9 | SJEPD031175_D1.RNA-Seq | EPN | Posterior Fossa EPN | 0.881 |
| 10 | ERR2208948 | — | — | 0.881 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| HEDGEHOG_SIGNALING | 0.270 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.150 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.130 | Remibrutinib | — uncovered |
| TGF_BETA_SIGNALING | 0.110 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.070 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.050 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.030 | Idelalisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.020 | Inavolisib | — uncovered |