Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · mng-umap@100

MNG671

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4184cb1d-9baa-5869-a318-702845cbcb96

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.374
  • MITOTIC_SPINDLE+0.351
  • UV_RESPONSE_DN+0.317
  • ADIPOGENESIS+0.306
  • WNT_BETA_CATENIN_SIGNALING+0.304
  • PEROXISOME+0.288
  • PI3K_AKT_MTOR_SIGNALING+0.265
  • TGF_BETA_SIGNALING+0.216
  • INTERFERON_GAMMA_RESPONSE+0.212
  • APICAL_SURFACE+0.194

Top 10 suppressed

  • TNFA_SIGNALING_VIA_NFKB-0.421
  • PANCREAS_BETA_CELLS-0.387
  • SPERMATOGENESIS-0.301
  • ANGIOGENESIS-0.294
  • E2F_TARGETS-0.238
  • G2M_CHECKPOINT-0.182
  • P53_PATHWAY-0.163
  • KRAS_SIGNALING_DN-0.149
  • GLYCOLYSIS-0.140
  • HYPOXIA-0.136

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MNG693
mng-umap@100
——0.843
2MNG430
mng-umap@100
——0.776
3MNG633
mng-umap@100
——0.774
4MNG442
mng-umap@100
——0.757
5MNG525
mng-umap@100
——0.744
6MNG678
mng-umap@100
——0.727
7MNG1060
mng-umap@100
——0.719
8MNG805
mng-umap@100
——0.717
9MNG980
mng-umap@100
——0.708
10MNG1196
mng-umap@100
——0.705

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 24 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.374Inavolisib— uncovered
MITOTIC_SPINDLE0.351Inavolisib— uncovered
UV_RESPONSE_DN0.317Inavolisib— uncovered
ADIPOGENESIS0.306Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.304Inavolisib— uncovered
PEROXISOME0.288Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.265Inavolisib— uncovered
TGF_BETA_SIGNALING0.216Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.212Idelalisib— uncovered
APICAL_SURFACE0.194Temsirolimus— uncovered
ANDROGEN_RESPONSE0.171Inavolisib— uncovered
PROTEIN_SECRETION0.163Remibrutinib— uncovered
DNA_REPAIR0.152Idelalisib— uncovered
APICAL_JUNCTION0.151Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.147Inavolisib— uncovered
ALLOGRAFT_REJECTION0.119Idelalisib— uncovered
HEME_METABOLISM0.097Temsirolimus— uncovered
UNFOLDED_PROTEIN_RESPONSE0.083Idelalisib— uncovered
HEDGEHOG_SIGNALING0.070Inavolisib— uncovered
BILE_ACID_METABOLISM0.057Inavolisib— uncovered