Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · mng-umap@100

MNG525

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d8fac4a9-1c47-5138-84f1-df8a9087637f

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • WNT_BETA_CATENIN_SIGNALING+0.445
  • ALLOGRAFT_REJECTION+0.415
  • INTERFERON_ALPHA_RESPONSE+0.396
  • PROTEIN_SECRETION+0.305
  • INTERFERON_GAMMA_RESPONSE+0.304
  • UV_RESPONSE_DN+0.304
  • MITOTIC_SPINDLE+0.277
  • PI3K_AKT_MTOR_SIGNALING+0.267
  • INFLAMMATORY_RESPONSE+0.226
  • MYC_TARGETS_V1+0.224

Top 10 suppressed

  • TNFA_SIGNALING_VIA_NFKB-0.326
  • ESTROGEN_RESPONSE_LATE-0.271
  • KRAS_SIGNALING_DN-0.250
  • UV_RESPONSE_UP-0.245
  • OXIDATIVE_PHOSPHORYLATION-0.201
  • SPERMATOGENESIS-0.196
  • PANCREAS_BETA_CELLS-0.184
  • ESTROGEN_RESPONSE_EARLY-0.183
  • E2F_TARGETS-0.148
  • ANGIOGENESIS-0.124

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MNG1060
mng-umap@100
——0.806
2MNG442
mng-umap@100
——0.795
3MNG1174
mng-umap@100
——0.793
4MNG1046
mng-umap@100
——0.755
5MNG1182
mng-umap@100
——0.749
6MNG671
mng-umap@100
——0.744
7MNG746
mng-umap@100
——0.727
8MNG678
mng-umap@100
——0.719
9MNG1199
mng-umap@100
——0.716
10MNG1196
mng-umap@100
——0.716

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 32 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
WNT_BETA_CATENIN_SIGNALING0.445Inavolisib— uncovered
ALLOGRAFT_REJECTION0.415Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.396Inavolisib— uncovered
PROTEIN_SECRETION0.305Remibrutinib— uncovered
INTERFERON_GAMMA_RESPONSE0.304Idelalisib— uncovered
UV_RESPONSE_DN0.304Inavolisib— uncovered
MITOTIC_SPINDLE0.277Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.267Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.226Idelalisib— uncovered
MYC_TARGETS_V10.224Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.212Inavolisib— uncovered
HEDGEHOG_SIGNALING0.211Inavolisib— uncovered
PEROXISOME0.200Idelalisib— uncovered
HEME_METABOLISM0.176Temsirolimus— uncovered
COMPLEMENT0.159Inavolisib— uncovered
ANDROGEN_RESPONSE0.150Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.112Idelalisib— uncovered
MTORC1_SIGNALING0.101Inavolisib— uncovered
ADIPOGENESIS0.097Inavolisib— uncovered
FATTY_ACID_METABOLISM0.094Inavolisib— uncovered